Small companies in Asia

With the exit of Betfair and earlier on, problems faced by 888, it is rather obvious that the remaining players in the Asian space are the small to medium sized companies that face the threat or blessing of being bought by the giants like Party Gaming.
Is it the lack of understanding the complex systems existing in Asia or is Asia an impossible market? We believe that Party Gaming enter the USA market at the precise period when the companies are highly critical and did not have a good grasp of what works and not.